| abstract |
Drugs which contain cycloalka[b]pyridine-3-carbonylguanidine derivatives represented by general formula (1) and salts thereof and have inhibitory effects on sodium/proton (Na+/H+) exchange transport, wherein R1 represents hydrogen, halogeno, lower alkyl, lower alkoxy, aminated lower alkyl, lower alkoxyalkyl, aryl, a heterocycle, aralkyl, phenoxy-substituted lower alkyl or aralkyloxy-substituted lower alkyl; R2 represents hydrogen, halogeno, lower alkoxy or nitro; A represents a single bond or vinylene; B represents vinylene, etc.; D represents a single bond, methylene or ethylene; and E represents vinylene, etc. |