| abstract |
The invention relates to the finding that the yeast protein Skn7 acts as a transcription factor and is involved in direct binding to DNA. Transcription by Skn7 involves cooperation with other cellular factors, including the proteins Yap1, Hsf1 and Mbp1. The binding of Skn7 to specific DNA sequences, and its interaction with other factors, provides targets for assays for screening putative inhibitors of fungal growth. |