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filingDate 1998-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20e67c531de5da8941639034e94fc16b
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publicationDate 1998-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-9838218-A1
titleOfInvention Method for obtaining high-purity vwf or factor viii/vwf complex
abstract The invention relates to a method for obtaining high-purity vWF or factor VIII/vWF complex by immunoaffinity chromatography, characterized in that a vWF or factor VIII/vWF complex bound with an immune adsorbing agent is eluted with an elution agent containing a zwitterion as an essential active part, whilst preserving the molecular integrity of the vWF or factor VIII/vWF complex. The invention also relates to a preparation containing high-purity vWF with a specific activity of at least 100 U/mg protein obtainable by immunoaffinity chromatography and to the use of this preparation for producing a medicament for treating vWD or phenotypic hemophilia A.
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priorityDate 1997-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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