| abstract |
A method of inhibiting thrombin generation and complement activation is inhibited by using a dermatan disulfate having at least 2 sulfate groups per disaccharide obtained by chemical sulfation of native dermatan sulfate. The resulting dermatan disulfate having an average molecular weight from about 5000 to 35000 Daltons is characterized by high content (i) a high content of L-iduronic->4,6 di-O-sulfated-N-acetyl-D-galactosamine residues and (ii) a specific heparin cofactor II-mediated antithrombin activity, depending on average molecular weight, between about 25 to 125 u/mg. |