| abstract |
The present invention relates to compounds of Formula (I), which inhibit the growth of picornaviruses, such as rhinoviruses, Hepatitus viruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus, wherein: R is C1-C6 alkyl, phenyl, or substituted phenyl; Y and Y1 are independently hydrogen, halo, nitro, or trifluoromethyl; X is N-OH, O, or CHR1; R1 is hydrogen, halo, CN, C¿1?-C4 alkyl, -C CH, CONR?2R3, COR2¿, or CO¿2?R?2; R2 and R3¿ are independently hydrogen or C¿1?-C4 alkyl; or a pharmaceutically acceptable salt thereof. |