Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9b442f17c57e6903e584b8486085ac9 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10322 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10362 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-93 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-861 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00 |
filingDate |
1997-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c820851af535e0ae76ed70fee12451cb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c66bf4ea1546a85fce7844aede6b2bcc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48b135e1c82baf4164b2d9585157ff91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f56c9df73e125d983b83439c84e7d59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d95953dd253d2e8024e7129fb46c771e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80de8ef2f6282d628a0659e459bec0f1 |
publicationDate |
1998-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-9829555-A2 |
titleOfInvention |
Cytopathic viruses for therapy and prophylaxis of neoplasia |
abstract |
Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 and/or RB function. The mutant virus is able to substantially produce a replication phenotype in non-replicating, non-neoplastic cells having essentially normal p53 and/or RB function. The preferential generation of replication phenotype in neoplastic cells results in a preferential killing of the neoplastic cells, either directly or by expression of a cytotoxic gene in cells expressing a viral replication phenotype. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7364727-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7276233-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10300096-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8133481-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10731136-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6326356-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6197754-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11268073-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10155930-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2004505633-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7048920-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6911200-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9959604-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7371570-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10538744-B2 |
priorityDate |
1996-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |