| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_60da379fb33c192ef77f86a60c5ac029 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate |
1997-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f326d63ddd53ebf9b14d0428c0b9b06f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ffa889343eff0120a28da7b031d8eab
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33b99e9bdfdb966f7a0bb81bb6d46bc9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85de80b7e24cbd34098d7b72119f9391
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f66362f81b45a0fba8ba808b99354f4 |
| publicationDate |
1998-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9827209-A1 |
| titleOfInvention |
Polycationic oligomers |
| abstract |
The present invention relates to improved methods for introducing nucleic acid into cells by first complexing the nucleic acid with a selected polycationic oligomer which neutralizes the negative charge of the nucleic acid, and then contacting the cell with the complex facilitating uptake of the nucleic acid into the cells as a complex with the oligomer. The methods are preferably applied to introduction of nucleic acid into eukaryotic cells, and more preferably into human cells. The invention also relates to methods of introducing antisense and triplex-forming oligonucleotides into prostate cancer cells to inhibit expression of proteins associated with (or that promote) malignancy and to inhibit cell growth or proliferation. More particularly, the invention relates to a method for inhibiting the expression of the HER-2/NEU protein in prostate cancer cells and to a method for inhibiting prostate cancer cell growth or proliferation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6197332-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6958325-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9908711-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7214384-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7001891-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6569450-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6572881-B1 |
| priorityDate |
1996-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |