| abstract |
Compounds of the formula (I) Cyclo-(Arg-X-Asp-R<1>) in which X means Gly, Ala or NH-NH-CO, R<1> means a radical of formula (II), and R<2>, R<3>, and R<4> have the meanings given in claim 1, and their salts, can be used as integrin inhibitors, in particular for the prevention and treatment of circulatory diseases, in cases of thrombosis, cardiac infarction, coronary heart disease, arteriosclerosis, pathological symptoms that are sustained or propagated by angiogenesis, and in tumour therapy. |