| abstract |
The present invention relates to novel pyrrolizine derivatives of formula (1), their salts or their solvates, and relates to the use of the compounds as anti-tumor medicines or as site-specific DNA alkylating agents in the gene relating technologies, the compounds and their salts which are so soluble into water-soluble solvents and stable in bodies as to be capable of being used as anti-tumor medicines and in addition to this, can be so bound with the materials site-specifically bound with nucleic acid such as oligonucleotides, peptide analogs and cholesterols, as to be used in the gene relating technologies. In formula (1), R1, X, X', Y and n are the same as defined in the specification. |