http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9825630-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff81a650b70e913d3b2524b45e4c7320 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y202-01002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1022 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10 |
| filingDate | 1997-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f41d5702c639a7c026cebcda6fa48ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1d9785802d5ec56785a8b3cf91ab362 |
| publicationDate | 1998-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9825630-A1 |
| titleOfInvention | Transaldolase-mediated regulation of apoptosis |
| abstract | Transaldolase (TAL) plays an important role in regulating the sensitivity of cells to apoptosis. Methods which upregulate TAL gene expression, such as by delivery of exogenous TAL-encoding DNA to a cell, or methods which stimulate TAL enzymatic activity, such as induction of phosphorylation through protein kinase C, promote programmed cell death in response to apoptotic signals. Conversely, inhibition of TAL gene expression, such as by delivery of TAL antisense DNA, or the suppression of TAL enzymatic activity, renders the cell resistant to apoptotic signalling. The present invention provides approaches to the treatment of conditions characterized by enhanced apoptosis, for example, neurodegenerative diseases, demyelinating diseases or HIV disease, or conditions in which apoptosis is inappropriately suppressed, for example cancer, certain virus infections and autoimmunity, by the appropriate up- or down-regulation of TAL expression or TAL enzymatic activity. |
| priorityDate | 1996-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 270.