| abstract |
The invention pertains to novel methods for preventing or arresting invasive remodelling in mammals by utilising a combination of in vivo inhibition of plasmin and in vivo inhibition of certain other proteolytic enzymes, notably metalloproteases. The method can e.g. be used as a novel alternative to current methods of contraception as well as antifungal and antibacterial treatment. The preferred embodiments relate to treatment and prevention of neoplastic diseases by use of these combinations. Further, the invention relates to novel compositions which comprises a plasmin inhibitor in admixture with an inhibitor of another proteolytic enzyme, preferably an inhibitor of a metalloprotease. |