| abstract |
Erythromycin A derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof, each having a potent antibacterial activity against not only conventional erythromycin-sensitive bacteria but also erythromycin-resistant bacteria, wherein R?1 and R2¿ represent each group (a), group (b), pyridylacetyl, C¿4?-C8 cycloalkylmethyl, 1,2-bis(ethoxycarbonyl)vinyl, etc.; and A represents a group represented by -OC(=O)-R?17¿, -OC(=O)-CH¿2R?17, -OC(=O)-NH-R?17, -O-R17¿ or -OC(=O)-O-R17. |