| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6bffe64bd33177ac47cf7e9fa0527399
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e13cc0d19244fdfb326c0588ea6b5527 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0647
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2884
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0789
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate |
1997-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_907ed18bb4a8730519d51e41b39088f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a92c2e7e3eaee9182f2c81adc743bae |
| publicationDate |
1998-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9822508-A2 |
| titleOfInvention |
Process for tumour cell depletion of cd34-positive cells |
| abstract |
A process for selectively eliminating (purging) tumour cells from preparations containing CD34-positive cells using CD44-specific antibodies is disclosed. The invention is based on the surprising discovery that CD34-positive cells, unlike many tumour cells, do not express the variant exons CD44v5 and CD44vt, or only to a very minor extent. A new molecular marker is thus provided by means of which tumour cells that contaminate strain cell preparations can be selectively destroyed. To destroy tumour cells, CD44v-specific antibody molecules can be linked to a cytotoxic agent, for example the exotoxin of the species pseudomonas. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7361347-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02094325-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004018000-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02094325-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004018000-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1391213-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1258255-A1 |
| priorityDate |
1996-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |