| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9483888dfbdffe4ae5c217508d41dad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2045aa878ca266937071945084295e10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f6869c7f0f9716edaa605af291dd2b74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03e59166d961db8d94696844857d97c4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f84747e8d08b1023763356d0e7d1db68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ee0f24249d421d3e41d36da133133783 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-01007
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-465
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-34 |
| filingDate |
1997-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59b8740efd51d98c1b866e9197a66722
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5444ed6db2811daeef386e8064789c2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e430c73503d33538545c8a2b5253bb1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_431104fd3bee610dcf66d9d836f8c4a9 |
| publicationDate |
1998-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9822132-A1 |
| titleOfInvention |
A method and composition for enabling passage through the blood-brain barrier |
| abstract |
A pharmaceutical composition for facilitating passage of compounds through the blood-brain barrier comprising the agent ACHE-I4 readthrough (SEQ ID No:1) splice variant or the I4 peptide (SEQ ID No:2) and analogues of each thereof and a pharmaceutically acceptable carrier is disclosed. Alternatively, the pharmaceutical composition for facilitating passage of compounds through the blood-brain barrier can comprise the agents adrenaline, atropine, dopamine and/or an adrenergic combination and a pharmaceutically acceptable carrier. The composition can comprise at least two of the agents. The composition of the present invention can optionally include the compound to be transported across the blood-brain barrier. Alternatively, the compound can be co-administered (simultaneously) with the composition or can be administered at some point during the biologically effective period of the action of the composition. The present invention provides a method for administering a compound to the CNS of an animal by subjecting the animal to a stress-mimicking agent or treatment. This agent or treatment facilitates disruption of the blood-brain barrier. During the period that the BBB is opened or disrupted a compound can be administered such that the compound is enabled to pass through the disrupted BBB into the CNS. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7074915-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03087367-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0073427-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0073343-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7067486-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03087368-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03002739-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7063948-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0073343-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8546345-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8470792-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8946403-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7456154-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8202845-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8541384-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03087367-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0073427-A3 |
| priorityDate |
1996-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |