| abstract |
A combination of a first compound of an oligo- or polysaccharide containing aminosugar units and a second compound of a sulfated mono-, di- or oligosaccharide as an agent for the enhancement of the healing of wounds in collagen containing tissues, including skin and bone and in mucosa. The first compound may be, e.g., chitosan, chitosans obtained by deacetylated of chitin to various degrees of deacetylation, chitosan derivatives, glycosaminoglycans including chondroitin, chondroitin sulfate, hyaluronic acid, dermatan sulfate and keratan sulfate; aminated dextrans including DEAE-dextran; aminated starch, aminated glycogen, aminated cellulose, aminated pectin, heparin, and salts, complexes, derivatives and mixtures thereof, and the second compound may be a disaccharide such as, e.g., sucrose, a sucrose derivative or a complex or a salt thereof, wherein the disaccharide is at least tetrasulfated. A very interesting combination is a combination of chitosan as the first compound and sucrose octasulfate as the second compound. Also disclosed is the use of such compounds as medicaments, pharmaceutical compositions containing such combinations and a method for the preparation of such combinations. |