Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_94ff2d78578d95d1e8d3a2233c76188d |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5078 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-4891 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-48 |
filingDate |
1996-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfe3f905812b8558694469433c77e684 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0290ffd025d5f85badf471c00110262b |
publicationDate |
1998-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-9822096-A1 |
titleOfInvention |
Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery |
abstract |
The present invention relates to a pharmaceutical composition in a unit dosage form for peroral administration in a human or lower animal, having a gastrointestinal tract comprising a small intestine and a colon with a lumen therethrough having an inlet to the colon from the small intestine, comprising: a) a safe and effective amount of a therapeutically active agent incorporated into or coated on the surface of a dosage form selected from the group consisting of a spherical substrate, an elliptical substrate, a hard capsule, or a compressed tablet, with a maximum diameter of about 3 mm to about 10 mm; and b) an enteric polymer coating material comprising at least one inner coating layer and one outer coating layer; wherein the dosage form has a smooth surface free from edges or sharp curves; the elliptical substrate and the hard capsule have a ratio of the long to short diameters of no greater than about 1.5; the therapeutically active agent is released at a point near the inlet to, or within the colon; each of the inner coating layer(s) is an enteric polymer that begins to dissolve in an aqueous media at a pH between about 5 to about 6.3; and the outer coating layer is an enteric polymer that begins to dissolve in an aqueous media at a pH between about 6.8 to about 7.2. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1108431-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2461802-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014154677-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2738114-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10449158-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014044794-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104797243-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011110344-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11622938-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2371356-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014044794-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9682101-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11712422-B2 |
priorityDate |
1996-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |