| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_de97c65d5e53184c1fff621cae39570a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_82f4b9d8d223a57b12b34759f7429cbb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2613944636ab2fdf3f83ef2d4b304f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b246b9af6590ad7e28e48c8fb6af4449 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-41
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-41
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-10 |
| filingDate |
1997-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b727831fbc1c56433b007e283bbe54e7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95bb19f9b556aa13edb659f09bc1f9d9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da926b0cf173f2c18e418ef88165ac88 |
| publicationDate |
1998-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9817623-A3 |
| titleOfInvention |
Polyamine transport inhibitors |
| abstract |
The present invention describes the design, synthesis and therapeutic use of a variety of novel inhibitors of polyamine transport. The main feature of this class of transport inhibitors is to incorporate a linker or side chain that prevents the uptake of polyamines and helps to conjugate polyamine analogs to form dimers with high inhibitory potency against polyamine uptake. These new compounds incorporate features that are designed to maximize their chemical and metabolic stability and their ability to bind to the polyamine transporter, and to minimize their toxicity by preventing their absorption by the cells. The purpose of such inhibitors is to prevent the uptake or salvaging of circulating polyamines by rapidly proliferating cells such as tumor cells, in order to potentiate the effect of therapeutic inhibitors of polyamine biosynthesis such as Eflornithine. |
| priorityDate |
1996-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |