| abstract |
Disclosed are piperidine-keto acid derivates of general formula (I) and their tautomeric and isomeric forms, as well as their physiologically well tolerated salts, where R<1> can mean -CO-R<4>, -SO<2>-R<4>, -CONH-R<4>, -COOR<4>, -C(=N)-R<4>, -C(=O)-NHR<4> and -C(=S)-NHR<4>; R<2> can have the meaning -C1-C6-alkyl, whether branched or not, and can still carry a phenyl, a pyridine or a naphthyl-ring, which can possibly be substituted with no more than two R<5> residues, while R<5> C1-C4-alkyl, whether branched or not, can mean -O-C1-C4-alkyl, OH, Cl, F, Br, J, CF3, NO2, NH2, CN, COOH, COO-C1-C4-alkyl, -NHCO-C1-C4-alkyl, -NHCOPh, -NHSO2-C1-C4-alkyl, NHSO2-Ph, -SO2-C1-C4-alkyl and -SO2Ph; and R<3> can mean -OR<6> and -NHR<6>. The preparation of the inventive compounds and their use as drug products are also disclosed. |