| abstract |
The invention relates to the discovery, identification and use of laminin, laminin-derived protein fragments, and laminin-derived polypeptides, as well as related peptides and antibodies, for the therapeutic intervention and diagnosis of Alzheimer's disease and other amyloidoses. In addition, the discovery and identification of an Alzheimer's beta-amyloid protein specific binding within the globular domain repeats of the laminin A chain, had led to new diagnostic and therapeutic applications for Alzheimer's disease and other amyloidoses which are disclosed. |