| abstract |
The host-cell adhesion by human influenza viruses is inhibited by new compounds of the general formula (1), where R1 stands for acyl or a thioacyl group; R2 for hydroxyl, Z-alkyl, substituted Z-alkyl, Z-aryl, substituted Z-aryl, and Z corresponds to O, S or NH; R3 stands for an acyl or a thioacyl group; R4 for H or acyl; X for O, S, SH¿2? or a sugar; and where W is a bifunctional spacer and P a multivalent vector consisting of one of the following substances: polyacrylate, polyacrylamide, N-substituted polyacrylamide, metacrylamide, N-substituted metacrylamide, polyacrylic acid, polycarbonate, polyester, polyamide, polyanhydride, polyiminocarbonate, polyorthoester, polydioxanone, polyphosphazene, polyhydroxy carboxylic acid, polyamino acid, polysaccharide, protein, dextran, chitosan, glucan, liposome, microparticles. The inventive compounds are capable of bonding authentic human viruses from the A (H1 and H3) groups, which have not been adapted through culturing in chicken eggs. |