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filingDate 1997-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1998-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-9814135-A1
titleOfInvention Magnetically oriented tissue-equivalent and biopolymer rods
abstract Tissue-equivalent and biopolymer tubes and rods include fibrils which are oriented (aligned) by a magnetic field. These oriented fibrils provide enhanced mechanical and cell guidance properties to the tissue-equivalent and biopolymer tubes. One such tissue-equivalent tube includes a body of collagen gel with mammalian tissue cells interspersed therein. The collagen fibrils are circumferentially oriented within the tubular body by a magnetic field, thereby inducing circumferential orientation of the cells. One such biopolymer rod includes collagen fibrils longitudinally oriented along the rod axis by a magnetic field that guides invasion of cells. Methods of making magnetically oriented tissue-equivalent and biopolymer tubes and rods are also disclosed.
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