http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9808865-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_039e7e06657a81d3b055a4079fb9da57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7a6c2ab82b6895dbaf6c99501f76f6a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2253d4109af8824a438cb92468bbda0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4705 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate | 1997-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03190348b7e50a2f08d6e6dce4697d41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c6d2c181edfa2857740551bddebc4e2 |
| publicationDate | 1998-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9808865-A1 |
| titleOfInvention | CAP-BINDING DOMAIN OF HUMAN EUKARYOTIC PROTEIN SYNTHESIS INITIATION FACTOR eIF-4E AND THE USE THEREOF |
| abstract | Binding of eIF-4E to the 5'm7G cap structure of eukaryotic mRNA signals the initiation of protein synthesis. In the present invention, the binding site cap-binding domain of eIF-4E was identified as the region containing the sequence Trp?113 to Arg122¿. Thus, in a first preferred embodiment the present invention provides a truncated peptide of the cap binding protein consisting essentially of the mRNA cap-binding domain. Specifically, the invention concerns eIF-4E cap binding peptide and its variants. In additional preferred embodiments, the invention provides an isolated nucleic acid molecule which encodes a truncated peptide of the eIF-4E protein consisting essentially of the mRNA cap-binding domain of eIF-4E; a recombinant vector and host cell comprising the above-described nucleic acid molecule; and a recombinant peptide produced thereby. The invention further provides the truncated or recombinant peptides immobilized on a solid support, a resin comprising the truncated or recombinant peptides immobilized on a solid support, methods and kits for isolating a capped mRNA molecule, and methods and kits for producing a full-length cDNA molecule. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6436676-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1326881-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7074556-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6841363-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9921985-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1326881-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0104289-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6703239-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6369199-B2 |
| priorityDate | 1996-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.