| abstract |
Compounds represented by general formula (I), pharmaceutically acceptable salts thereof, and hydrates of the same; and medicinal compositions such as endothelin receptor antagonists, remedies for peripheral circulatory insufficiency or macrophage foaming inhibitors containing these compounds. In said formula (I), R?1, R2, R3 and R4¿ independently represent each hydrogen, optionally substituted alkyl, hydroxy, optionally substituted alkoxy, etc.; R5 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted heterocycle, etc.; R6 represents hydrogen, optionally substituted alkyl, etc.; R7 represents hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, optionally substituted heterocycle, etc.; A represents S or O; and the broken line means the presence or absence of a bond. |