| abstract |
Compounds of formula (I) wherein R1 is aryl, heterocyclyl or heteroaryl; R2 is hydrogen, C¿1-8?alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, heteroaryl, heterocyclyl, arylC1-6alkyl, heteroarylC1-6alkyl, heterocyclylC1-6alkyl or C3-8cycloalkylC1-6alkyl; R?3¿ is C¿1-6?alkyl, C2-6alkenyl, aryl, C1-6alkyl, heteroarylC1-6alkyl or the side-chain of a naturally occurring amino acid; R?4¿ is hydrogen, C¿1-6?alkyl, C3-8cycloalkyl, C4-8cycloalkenyl, arylC1-6alkyl, heteroarylC1-6alkyl or heterocyclylC1-6alkyl; R?5¿ is hydrogen or C¿1-6?alkyl; or R?4 and R5¿ together with the nitrogen atom to which they are joined form a heterocyclic ring; wherein any group or ring, in R1-R5, is optionally substituted; or pharmaceutically acceptable salts or in vivo hydrolysable esters thereof, are described as inhibitors of the production of Tumor Necrosis Factor and/or one or more matrix metalloproteinase enzymes. Compositions containing them and their preparation are also described. |