abstract |
Phosphonate nucleotide compounds represented by general formula (I), their salts, hydrates and solvates thereof, and drugs containing the same, wherein R1 represents C¿1-6? alkyl, etc.; R?2¿ represents hydrogen, halogenated C¿1-4? alkyl, etc.; R?3¿ represents hydrogen, halogenated C¿1-4? alkyl, etc.; R?4¿ represents hydrogen, halogenated C¿1-4? alkyl, etc.; and X represents carbon or nitrogen. These drugs are useful as antiviral agents for human immunodeficiency virus, herpes simplex virus, hepatitis B virus, etc., and as antitumor agents. |