| abstract |
Hematopoietic stem cell proliferating agents containing IGF-I, optionally together with at least one protein selected from among SCF, M-CSF and G-CSF; and a process for proliferating hematopoietic stem cells characterized by culturing the cells in a medium containing IGF-I and at least one protein selected between M-CSF and SCF. Because of the capability of proliferating hematopoietic stem cells in a undifferentiated state either in vivo or in vitro, these agents are usable in the amelioration of cytopenia accompanying radiation therapy or induced by chemotherapeutics such as carcinostatic agents, the prevention of infectious diseasescaused by lymphocytopenia, the culture and proliferation of hematopoietic stem cells in vitro, the culture of recombinant stem cells in vitro in gene therapy, etc. |