| abstract |
A sustained release rectally administrable, and a delayed and sustained release oral composition is provided wherein the active in diamorphine, morphine, cocaine, theophylline, aminophylline, phenytoin, carbamazepine, phenobarbitone, cyclosporin, diazapam, nitrazepam, temazapam. In a preferred form of these compositions, the active is absorbed predominantly from the colon and provides for reduced peak plasma concentration of active, which otherwise give rise to addiction and other adverse side effects. In some cases, the active is present as a complex in with a carbomer, which provides for enhanced sustained release and therefore more uniform blood plasma concentrations of active. |