| abstract |
Methods for treating diseases associated with toxicity of Apolipoprotein E ("apoE"). Specifically, the present invention relates to new methods for treating a mammal having a condition associated with toxicity of apolipoprotein E cleavage fragments containing residues 130-169, comprising administering to said mammal a pharmacologically effective amount of compound or a pharmaceutically acceptable salt, derivative or fragment thereof to interfere with generation of toxic fragments of apolipoprotein E or with the receptor-binding site associated with residues 130-169 of the apolipoprotein E molecule in said mammal. |