| abstract |
Depsipeptides represented by general formula (1) or pharmacologically acceptable salts thereof, wherein R1 represents linear or branched C5-20 alkyl or linear or branched C5-15 alcoxymethyl; R2 represents -A-B, -A-B-W, -A-B-W-D or -A-B-W-D-E; and R3 represents hydroxy, lower alkoxy, benzyloxy, -Z, -Z-G or -Z-G-J, wherein A, B, D, E, G and J independently represent each an amino acid residue selected from among alanine, valine, leucine, isoleucine, serine, threonine, lysine, hydroxylysine, arginine, cysteine, methionine, phenylalanine, tyrosine, aspartic acid, asparagine, glutamic acid, glutamine, etc. optionally bonded to N-(C1-4 alkyl); W and Z independently represent each an animo acid residue selected from among aspartic acid, asparagine, glutamic acid, glutamine, alanine, serine, and lysine. These depsipeptides have the effects of promoting apolipoprotein E production and are useful as remedies for nerve injury and, in particular, remedies for dementia. They are also useful as remedies for hyperlipemia. |