| abstract |
Peptides of 8 to 15 amino acids in length are described possessing neutrophil and/or monocyte/macrophage stimulatory activity. The peptides may be used in methods of treatment of various diseases and conditions in which enhancement of neutrophil and/or monocyte/macrophage function is desirable. The peptide is of the general formula: X1-X2-X3-X4-Ser-Thr-X5-Val-X6-Ile-Thr-X7-X8-X9-X10 in which, X1 is absent, Cys or R1; X2 is absent, Ala, Arg, Glu or Gly; X3 is absent, Ala, Arg, Asn, Cys, Glu, Gly, His, Ile, Leu, Lys, Met, Pro, Ser, Trp, η-Abu, βAla, Dbu, Sar, Suc or N-Me-Ala; X4 is absent, Ala, Arg, Asn, Glu, His, Leu, Lys, Met, Pro, Ser, Trp, βAla or Nip; X5 is Ala or His; X6 is Ala, Gly, Ile, Leu, Phe, Pro, Ser, Thr, Trp, Val, D-Ala, D-Ile, D-Pro, D-Ser, D-Thr, D-Val or βAla; X7 is His or Ala; X8 is absent, Ile, Ley, Thr or D-Ile; X9 is absent, Ile, D-Ile or Aib; and X10 is absent, Cys or R2. |