| abstract |
This invention relates to pyrrolo[1,2-a]pyrazine-1,4-diones of general formula (I), wherein B is carbonyl or methylene, R?2, R4, R5, and R6¿ are hydrogen, alkyl, or substituted alkyl, A is a basic group, and Q is hydrogen or a keto heterocycle group. The compounds are inhibitors of serine proteases, typically thrombin, Factor Xa, and Factor VIIa, and are useful for treating and preventing thrombotic disorders. |