| abstract |
This invention relates to locally administrable, biodegradable and sustained-release pharmaceutical composition for periodontitis and process for preparation thereof, which can show continuous drug effect for a long time by controlling the release time and by making drug remain in the periodontal pocket for prolonged time wherein they are prepared by i) making the microsphere containing the physiologically active substance, ii) making the mixture of the microspheres and water-soluble polymer such as polysaccharides, iii) making the mixture into the form of film or strip or/and iv) coating the film or strip with cation aqueous solution such as calcium and barium. The present pharmaceutical composition can be easily administered using forceps, minimized side effect and maximized the effect by releasing the active substance at the minimum dose, and make the patients feel comfortable. |