| abstract |
This invention relates to a depigmenting agent, particularly a depigmenting compound containing a combination of corticosteroid and lincosamide. The corticosteroid of this invention may be selected from cortisol, cortisone, cortisterone, deoxycortisterone, aldosterone, prednisolone, triamcinolone, paramethasone, or betamethasone, dexamethasone; it is preferred to select betamethasone or dexamethasone, and its contents are in the range of 0.01 to 10 %, preferably in the range of 0.04 to 1 %. The lincosamide of this invention may be selected from lincomycin or clindamycin and its contents are in the range of 0.1 to 50 %, preferably in the range of 0.1 to 5 %. According to this invention, the formulation of a depigmenting agent may include a skin cream containing ointment base, additionally, lotion, solution, suspension, ointment, aerosol (spray), foam, paste, gel, or patch preparation. The depigmenting agent of this invention has a remarkable depigmenting effect with less side effects. |