http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9739122-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a9fdcfc016d06837fd8ffcda67af9542 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_19e927a2a0ffaa23ee591aab449994cf |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-52 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-52 |
| filingDate | 1997-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf2653c56d5b0a4709f681a34a0740b2 |
| publicationDate | 1997-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9739122-A3 |
| titleOfInvention | Isolated and cloned mast cell 78 kda phosphoprotein (mast cell degranulation inhibitory agent) and use thereof |
| abstract | A 78 kDa mast cell protein (moesin) has been cloned from rats, and its cDNA and amino acid sequence determined. This protein is phosphorylated on specific serine and threonine residues by the action in mast cells of one or more protein kinase C isozymes, especially the κ isozyme, thereby producing a phosphoprotein that inhibits mast cell degranulation (Mast Cell Degranulation Inhibitor Agent). In vivo phosphorylation of this protein in mast cells can be stimulated by drugs such as cromolyn, nedocromil, flavonoids such as quercetin and kaempherol, and lodoxamide. Mast cell degranulation can be inhibited by administration of phosphomoesin phosphatase inhibitors. Tissues deficient in mast cell moesin can be identified with a labeled anti-moesin or anti-phosphomoesin antibody and treated by transfecting such mast cells with moesin cDNA in a viral vector such as an influenza virus vector. |
| priorityDate | 1996-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.