| abstract |
Viral vectors are targeted to selected cell types by blocking the wild-type viral cell binding site and incorporating a targeting agent into the vector particle. The targeting agent binds to the selected cell type by binding a molecule on the surface of the cell, or by binding a second targeting agent which binds the selected cell. Parvovirus, retrovirus, Herpes virus and Ad virus based vectors are provided. Libraries of viral vectors having the targeting agent are provided. Methods of selecting recombinant viral vectors from the libraries are also provided. Polypeptide ligands isolated from libraries of phage or viral vectors are provided. |