http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9735478-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_80c4d25ecb2b8fa4b81eb74cabc67bee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70571 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 |
| filingDate | 1997-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebe7c97a1f7280f4b3c10ab21868a38d |
| publicationDate | 1997-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9735478-A1 |
| titleOfInvention | Selective target cell activation by expression of a g protein-coupled receptor activated superiorly by synthetic ligand |
| abstract | The invention provides a method for selectively activating a target cell, where the target cell expresses a receptor activated superiorly by a synthetic ligand (RASSL) having decreased binding affinity for a selected natural ligand and normal or near normal binding affinity for a synthetic small molecule agonist. Thus, RASSL-mediated activation of target cells does not occur to a significant extent in the presence of natural G protein-coupled receptor ligand, but is significantly stimulated upon exposure to a synthetic small molecule. RASSL-expressing target cells are selectively activated by exposing of the cells to an appropriate synthetic small molecule, which in turn binds the RASSL, resulting in G protein activation and triggering of a specific cellular response associated with G protein activation (e.g., cellular proliferation or cellular secretion). |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10525103-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10391145-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9284358-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022238513-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9717775-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015136247-A1 |
| priorityDate | 1996-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1115.