| abstract |
This invention relates to a suppository composition containing a drug which has gastro-intestinal disturbances or undergoes the decomposition by gastric acid, poloxamer and hydrophilic natural polymers. The suppository composition of this invention is characterized in that it has a gelation temperature of 30 to 36 °C, and is a liquid form at room temperature, and readily becomes a gel at body temperature after rectal administration; it has the remarkable gel strength, and is not leaked out the anus; it has the remarkable bioadhesive force, and doesn't climb up to the end of the colon, therefore ensures absorption of the drug without gastro-intestinal disturbances or the decomposition by gastric acid. |