| abstract |
Compounds of general formula (I) exhibiting an estrogenic activity and/or anti-estrogenic activity, geometrical isomers of them, and pharmaceutically acceptable salts thereof, wherein R0 is hydrogen or a hydroxyl-protecting group; R1 is hydrogen, halogeno, C¿1?-C6 alkyl, hydroxyl or protected hydroxyl; R?2¿ is hydrogen or -(CH¿2?)k-X-R?3¿; the solid lines with short dashes are each a single bond or a double bond; A is (1) methylene, oxygen or a single bond, or (2) methyne; E is (1) -GR7- or -CO-, or (2) =CR7- or nitrogen; and Z is carboxyl, carbamoyl, hydroxyaminocarbonyl, hydroxymethyl or a protected functional group derived therefrom. |