| abstract |
Optically active 1,4-dihydropyridine derivatives of general formula (I), salts thereof with anions, and a process for the preparation thereof (wherein R1 is C1-C6 alkyl; R2 is a quaternary ammonium group derived from an optionally substituted nitrogenous heterocyclic group; and n is 1, 2 or 3). The above derivatives of general formula (I) exhibit vasodilating and antihypertensive activities and are excellent in water solubility, thus being useful as drugs for circulatory diseases, such as antihypertensive and vasodilator. |