| abstract |
This invention relates to a suppository composition containing a drug which undergoes the hepatic first-pass effect, poloxamer and hydrophilic natural polymers. The suppository composition of this invention is characterized in that: has the gelation temperature of 30 to 36 °C, and is a liquid form at room temperature, and readily becomes a gel at body temperature after rectal administration; has the remarkable gel strength, and is not leaked out the anus; has the remarkable bioadhesive force, and doesn't climb up to the end of the colon, therefore ensures better bioavailability of the drug. |