| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_916075766043ce900399a4c2eee9f054
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6f79749e86afce9444a364ab60ca3584 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4703
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0004 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate |
1997-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d32b182e4fee6c38c7ee98c3f06ef72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e1c3fa9da4be1db801ee1c0cf135e24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ada6ae38349d22ed5684855efb2dda5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf70fc2adda46135e1efbe429573f6a6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_983b84aa9710413e8e19c36f86ccf5ea
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70db914409563c600cfe21500d98d447
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81a6290c18ad419f3fad79abf33759bc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d4d5a02a62db3c9634ab4643f533bff |
| publicationDate |
1997-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9730108-A1 |
| titleOfInvention |
Characterized brca1 and brca2 proteins and screening and therapeutic methods based on characterized brca1 and brca2 proteins |
| abstract |
Genetic analysis of familial breast and ovarian cancer indicates that BRCA1 is a tumor suppressor gene. The BRCA1 gene encodes a 190 kDa protein with sequence homology and biochemical analogy to the granin family of proteins. Granins are secreted from endocrine cells via the regulated secretory pathway and are proteolytically cleaved to yield biologically active peptides. BRCA1 protein localises to secretory vesicles, and was demonstrated to be secreted. Gene transfer of BRCA1 inhibits growth and tumorigenesis of breast and ovarian cancer cells, but not colon or lung cancer cells or fibroplasts, suggesting that BRCA1 encodes a tissue-specific growth inhibitor. Thus, BRCA1 is a secreted growth inhibitor and functions by a mechanism not previously described for tumor suppressor genes. The BRCA2 breast and ovarian cancer gene encodes a protein that also includes a granin region, indicating that the BRCA2 protein is also a secreted tumor suppressor. Therapeutic methods using the BRCA1 and BRCA proteins and genes are also described. A method of screening for the receptors of the BRCA1 protein and BRCA2 proteins is also described. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109929804-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9936562-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9812327-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109929804-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6492109-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9909164-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6686163-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9812327-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6838256-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100468466-B1 |
| priorityDate |
1996-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |