| abstract |
A compound having structure (I) wherein (a) n is from 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO2; (c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from 3 to 7 atoms other than hydrogen; (d) Z is hydrogen or straight, branched or cyclic alkyl; Z having from 3 to about 10 atoms other than hydrogen; (e) R1 is hydrogen or straight, branched or cyclic alkyl, halo, carboxyl, carboxamido, alkoxycarbonyl or alkylcarbonyl; (f) T is O or S; (g) U is O, S, N or N-R2; (h) W is CR3R4, C=O, C=S, C=NR5, C-O-R6, C-S-R6, C-NH2, C-NH-R7, or C-NR6R7; (i) V is (CH2)n, O, S, or N-R2; (j) R2 is hydrogen, alkyl, hydroxy, alkoxy, alkoxycarbonyl, or alkylcarbonyl; (k) R3 and R4 are independently selected from the group consisting of hydrogen, alkyl, halo, hydroxy, alkoxy, mercapto, alkylthio, or cyano; (l) R5 is hydrogen, alkyl, hydroxy or alkoxy; (j) R6 is hydrogen or alkyl; and (k) R7 is hydrogen, alkyl or C(=NH)N(R6)2. Pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds. |