| abstract |
An apparatus and related system for small scale processing of solutions. A preferred apparatus is provided in the form of a disposable tip comprising a polymeric housing having a rigid wall portion forming an internal passageway having a longitudinal axis, and a depth filter sealably positioned within the internal passageway. Optionally, the tip provides means for sealably attaching the tip to other devices, either directly or by means of suitable adaptors, at either or both ends of the passageway. The filtration tip can be used in a system of the invention for small scale incubation of samples, e.g., in the course of an assay, reaction, synthesis, binding, extraction, clarification, concentration and the like. An apparatus that includes a hydrophobic support material finds particular use in a method for the preparation of purified oligonucleotides. |