http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9724357-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4be65d64fe39b8d5ea93345d0d4fbe26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba21c4123db789685f1f3388ca1ea7c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f66a5c8ebc9f789ac4d6fdf7dfc1f2a9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-00 |
| filingDate | 1996-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e50423228334bd95c4c261c8fbf549a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2773eebd186451148e9e087ec51f241d |
| publicationDate | 1997-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9724357-A1 |
| titleOfInvention | Process for synthesis and purification of a compound useful in the preparation of acyclovir |
| abstract | Intermediate chemical compounds useful in the preparation of acyclovir and a method of synthesizing and purifying the intermediate chemical compounds. Diacetyl-guanine is alkylated and the resulting product washed with an alcohol to produce a relatively pure, crystalline diacetyl-acyclovir (DA-ACV). The diacetyl-acyclovir (DA-ACV) is hydrolyzed in the presence of potassium hydroxide to a novel potassium salt of acyclovir, acyclovir potassium enolate. The acyclovir potassium salt is converted into essentially pure acyclovir. The step of hydrolyzing diacetyl-acyclovir and forming the potassium salt occurs simultaneously. The potassium salt of acyclovir is converted to acyclovir by dissolving in water in the presence of an acid to generate an essentially pure acyclovir. The resulting acyclovir normally needs no further purification and meets the specification of U.S.P. XXIII. Thus, the invention is directed to the synthesis of intermediate purified diacetyl-acyclovir, the conversion of the diacetyl-acyclovir to an acyclovir-potassium salt, and the conversion of the acyclovir-potassium salt to acyclovir. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112300166-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113620955-A |
| priorityDate | 1995-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.