| abstract |
Tetrazole derivatives represented by general formula (I), nontoxic salts thereof, and drugs containing the same as the active ingredient. Because of having an inhibitory effect on the interleukin-1β converter enzyme, the compounds of general formula (I) are useful in the prevention and/or treatment of various inflammatory diseases, wherein R1 represents H, alkyl, alkoxy, a carbocycle, a heterocycle, alkyl or alkoxy substituted by a carbocycle or a heterocycle, etc.; AA1 represents a single bond or (i); AA2 represents a single bond or (ii); or AA?1 and AA2¿ may together form a group of formula (a); Y represents a group of formula (b) wherein the Tet ring represents a tetrazole ring; Z represents alkylene, alkenylene, O, S, SO, SO¿2, NR?26 or alkylene wherein methylene is substituted by O, S, SO, SO¿2? or NR?26¿; and E represents H, alkyl, COOR27 or (iii), wherein the Cyc ring represents a carbocycle or a heterocycle. |