http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9724326-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03627f82d4edc6567f9627df6efdde5d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-90 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-90 |
| filingDate | 1996-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1700c64c5024d54bb4f11a85733c6b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6745f6950f9bbbb7f336b35242308d6a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_421ea1bbd6172aae26ca458df9adbd2c |
| publicationDate | 1997-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9724326-A1 |
| titleOfInvention | Process to prepare dihydropyridine and derivatives thereof |
| abstract | A novel process is disclosed for the preparation of dihydropyridine compounds and derivatives thereof, and more particularly felodipine. The process to prepare felodipine involves a two step procedure condensing 2,3-dichlorobenzaldehyde with methyl acetoacetate in the presence of a catalyst system. The resultant benzylidine intermediate is sequentially reacted with ethyl aminocrotonate to provide felodipine. The novelty of the present invention resides in part on (1) a new catalyst system not previously disclosed for the preparation of felodipine, (2) the absence of acid(s), (3) the control of reaction conditions to yield lower amounts of unreacted aldehyde compared to known reactions, (4) a simplified purification process, and (5) formation of negligible quantities of symmetrical diester byproducts. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104177286-A |
| priorityDate | 1995-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 179.