| abstract |
Thiazole derivatives of general formula (I) and salts thereof, exhibiting both leukotriene D4 and thromboxane A2 receptor antagonisms. In formula (I), X is carbonyl or sulfonyl; Y is carboxyl, C1-C5 alkoxycarbonyl or 1H-tetrazol-5-yl; Z is C1-C5 alkyl, C3-C6 cycloalkyl or phenyl; W is C2-C5 alkylene or 1,4-cyclohexylene, and R is optionally subsituted phenylsulfonylamino, phenylsulfonyl, N'-phenylthioureido or C1-C5 alkylsulfonylamino. |