abstract |
The invention relates to a compound of formula (I) wherein A is a carbon-carbon double bond having the E or Z stereochemical configuration, or A is a carbon-carbon triple bond, Et is ethyl, and R is hydroxy and R1 is hydrogen or =CH¿2?, or R is hydrogen or fluoro and R?1¿ is =CH¿2?. They stimulate HL-60 cell differentiation and accordingly, are useful as agents for the treatment of neoplastic diseases, such as leukemia. |