| abstract |
Neurogenic differentiation genes and proteins from human, mouse, and frog are identified, isolated, and sequenced. Expression of neuroD1 has been demonstrated in neural, pancreatic, and gastrointestinal cells, and expression of neuroD2 was detected in brain. Ectopic expression of neuroD1 and neuroD2 in non-neuronal cells of Xenopus embryos induced formation of neurons. NeuroD1 knock-out mice had diabetes. |