| abstract |
Compounds of formula (I) wherein A represents (CH2)n in which one -CH2- moiety may be optionally replaced by O, -C(CH3)2 or -OC(CH3)2; and n is 1, 2 or 3; R1 represents hydrogen, C¿1-6?alkyl, C3-6cycloalkyl, C3-6cycloalkylC1-4alkyl, benzyl or 4-methoxybenzyl; R?2¿ represents a substituent selected from one or more of: a hydrogen or halogen atom, or a hydroxy, C¿1-4?alkyl, C1-4alkoxy, amino, mono-or di-C1-4alkylamino, trifluoromethyl, trifluoromethoxy, cyano, nitro, formyl, C1-4alkynoyl, or C?1-4¿alkoxycarbonyl group or a group R3R4NCO- wherein R?3 and R4¿ each independently represents a hydrogen atom or a C¿1-4?alkyl group or R?3R4¿N forms a 5-7 membered heterocyclic ring; m represents 1, 2, 3, or 4; Ar represents phenyl optionally substituted by 1 to 3 substituents selected from one or more of: halo, C¿1-4?alkyl, C1-4alkoxy, C1-2alkylenedioxy, trifluoromethyl, trifluoromethoxy, CN, NO2, amino, mono- or di-alkylamino, optionally substitued benzoyl or a group Ph(Alk?1)¿rY(Alk2)s- wherein Ph is optionally substituted phenyl, Y is oxygen or a bond, Alk1 and Alk2 each independenlty represents C¿1-4? alkyl which may be straight or branched and r and s are independently zero or 1, provided that the length of the chain (Alk?1)¿rY(Alk2)s does not exceed 5 atoms; or Ar represents an optionally substituted unsaturated monocyclic heteroaryl ring system containing 5 or 6 ring members, or an optionally substituted, unsaturated or partially saturated bicyclic aryl or heteroaryl ring system containing 8-10 ring members; and salt thereof are neuronal calcium channel antagonists useful in the treatment of ischaemic conditions e.g. stroke. |